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By 2028, virtually all major sensing and feedback systems benefiting from continuous monitoring will connect to devices currently known as the Internet of Things (IoT). As the pervasiveness of the IoT spreads, it will change completely how the world interacts with information. And, it will have a dramatic impact on mission-critical IoT devices and the applications they enable. Forget Industry 4.0 and think more in terms of Mission-Critical IoT 2.0. Rather than just devices optimized for performance, ultra-high reliability and security, it will be an entire mission-critical ecosystem designed and hardened to withstand the rigors of the real world. That ecosystem will enable functionality and deliver efficiencies that just a few years ago might have seemed impossible. But enabling that future will require the right technologies to build a strong foundation. This white paper outlines the key challenges you face across the 3 layers of the IoT ecosystem—device, wireless communications, and network and system—and details the technologies you need to overcome them and realize success in the mission-critical IoT.