Autozero is used to remove sources of error within the multimeter. When autozero is enabled the multimeter internally disconnects the input signal following each measurement, and takes a zero reading. It then subtracts the zero reading from the preceding reading. This prevents offset voltages present on the multimeter's input circuitry from affecting measurement accuracy. Autozero is always enabled for four-wire measurements but can be disabled for two-wire measurements.

When autozero is disabled, the multimeter takes one zero reading and subtracts it from all subsequent measurements. It takes a new zero reading each time you change the function, range, or integration time.