Making 4-wire resistance measurements - The 4-wire ohms method provides the most accurate way to measure small resistances. Test lead resistances and contact resistances are automatically reduced using this method. The connections for resistance measurements are shown below.

4-wire ohm measurement image

Using a known current source and measuring the voltage produced by the resistor the unknown resistance can be calculated.

Removing 2-wire Ohm Test Lead Resistance - For many applications a two-wire measurement will be more than adequate, it is easier to handle two probes, and the measurement is much faster.  The Null function can be used to eliminate offset errors associated with the test lead resistance in 2-wire ohms measurements.  The first step is to short the two leads together and wait for the DMM to display the resistance of the test leads.  The second step is to press the Null button.  The meter should now display a reading very close to zero.  Each subsequent reading will be the actual resistance measurement minus the initial null measurement (test lead resistance).

Learn about Keysight Digital Multimeter (DMM)