MAC Mode Imaging of Biological Molecules with AFM

Application Notes

One of the most appealing features of atomic force microscopy (AFM) for the field of biology is that it can operate in aqueous environments, making this technique capable of monitoring or measuring biological molecules under physiological conditions. In terms of AFM imaging, the complexity of probe oscillations and tip/sample force interactions in solutions is much higher than that under ambient conditions. For instance, ordering of the liquid at a solid interface is a ubiquitous phenomenon and such liquid structuring could have a profound effect on the operation of an AFM, causing the tip to hop between different stable configurations in the ordered region of the fluid.

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MAC Mode Imaging of Biological Molecules with AFM

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